Vitamins B6, B12 and folic acid

The use of these three B vitamins is associated with the reduction in total homocysteine levels in the blood. 30, 31

Although various studies have used different dosage in the course of their investigations, an effective dose seems to be 50 mg of vitamin B6, 100–300 mcg of vitamin B12, and 500–800 mcg of folic acid.

Changing diet appears not to affect levels of levels of homocysteine in the blood.

1.       Ubbink JB, Hayward WJ, van der Merwe A, et al. Vitamin requirements for the treatment of hyperhomocysteinemia in humans. J Nutr 1994;124:1927–33.

2.       Manson JB, Miller JW. The effects of vitamin B12, B6, and folate on blood homocysteine levels. Ann NY Acad Sci 1992;669:197–204 [review].

3.       Ubbink JB, Vermaak WJH, van der Merwe A, et al. Vitamin requirements for the treatment of hyperhomocysteinemia in humans. J Nutr 1994;124:1927–33.